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KMID : 0861019980130010083
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Korea Journal of Herbology
1998 Volume.13 No. 1 p.83 ~ p.93
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Effect of Lignum Aeschynomeni water extract on the renal functions and plasma aldosterone concentration in the rabbit
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Abstract
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To evaluate effect of Lignum Aeschynomeni water extract on the renal functions and plasma aldosterone concentration, experiments performed in the rabbit
The results obtained were followed :
1. Intravenous administration of Lignum Aeschynomeni water extract at the doses of 0.08㎖/㎏ significantly increased urine volume, glomerular filtration rate and urinary excretion of electrolytes.
2. Intravenous administration of Lignum Aeschynomeni water extract at the doses of 0.8㎖/㎏ remarkably decreased urine volume, free water clearance and glomerular filtration rate.
3. In travenous administratio of Lignum Aeschynomeni water extract at the doses of 0.08㎖/㎏ and 0.8㎖/㎏ significantly decreased plasma aldosterone concentration. These results suggest that Lignum Aeschynomeni water extract at the doses of 0.08㎖/㎏ has a diuretic effect which may be caused by renal hemodynamics and the decrement of aldosterone concentration, and that Anti diuretic effect of large dose may be relateo with Anti diuretic hormone.
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